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 Phycocyanin
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IMMUNE SYSTEM
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Phycocyanin
enhances secretary IgA antibody response
and suppresses allergic IgE antibody response
in mice immunized with antigen-entrapped
biodegradable microparticles.
Department of Health and Nutrition,
Kagawa Nutrition University, Chiyoda,
Sakado, Saitama 350-0288, Japan |
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Phycocyanin boosts the immune system In Japan, studies on mice suggests that phycocyanin raises lymphocyte activity and may increase survival of cancer-stricken organisms.
Iijima, N., Shimamatsu, H., et. Al. (inventors; Dainippon Ink x Chemicals assignee). Anti-tumor agent and method of treatment therewith. US Patent pending, ref. P1150-726-A82679, App. !5 Sep 1982. |
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ANTIOXIDANT & ANTI FREE-RADICALS
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C-phycocyanin:
a biliprotein with antioxidant, anti-inflammatory
and neuroprotective effects.
Departamento de Farmacologia, Centro Nacional
de Investigaciones Cientificas, Apartado
6412, Habana, Cuba. - Curr Protein Pept
Sci.2003 Jun; 4(3):207-16 |
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Analysis
revealed the antioxidant and antiurolithic
potential of phycocyanin thereby projecting
it as a promising therapeutic agent against
renal cell injury associated kidney stone
formation.
Department of Medical Biochemistry, Dr.
ALM Postgraduate Institute of Basic Medical
Sciences, University of Madras, Taramani,
Chennai 600113, India. chem. Biol Interact.
2004 Aug 10; 149(1):1-7 |
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C-phycocyanine
are able to reduce the steady state concentration
of the peroxyl radicals.
Department of Chemistry, Faculty of Chemistry
and Biology, Universidad de Santiago de
Chile, Santiago, Chile. Free radic boil
Med 2000 Apr 1; 28(7):1051-5 |
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Phycocyanin
is able to scavenge OH and RO radicals.
It also inhibits liver microsomal lipid
peroxidation.
Pharmacology Department, National
Center for Scientific Research, CNIC,
Havana, Cuba. Inflamm Res 1998 Jan:
47(1):36-41
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Increase
in phycocyanin content was related to
an increase in the antioxidant activity
in different fractions, and therefore
phycobiliprotein phycocyanin is the component
mainly responsible for the antioxidant
activity.
Departamento de Farmacologia, Facultad
de Farmacia, Universidad Complutense de
Madrid, Spain. Farmaco 2001 May-Jul:56(5-7):
497-500 |
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Study
has demonstrated that phycocyanin, a biliprotein
from spirulina platensis has the ability
to inhibit the ONOO(-), a potent physiological
inorganic toxin, hence has the potential
to be used as a therapeutic agent.
Chemical Biology
Unit, Jawaharlal Nehru Centre for Advanced
Scientific Research, Bangalore, India
Biochem Biophys Res Common 2001 jul
13; 285(2):262-6 |
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Phycocyanobilin
is responsible for the majority of the
antioxidative activity of phycocyanin
and may act as an effective antioxidant
in a living human body.
Takashi Hirata, Mikiya Tanaka, Masaki
Ooike, Teppei Tsunomura & Morihiko
Sakaguchi, Division of Applied Biosciences,
Graduate School of agriculture, Kyoto
Universite, Japan
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HEPATOPROTECTION & DETOXIFICATION
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C-phycocyanin
significantly decreases Kupffer cell phagocytosis
and the associated respiratory burst activity,
effects that may contribute to the abolition
of oxidative stress-induces TNF-alpha
response and NO production by hyperthyroid
state.
Centro de Investigaciones del Ozono, Centro
Nacional de Investigaciones Cientificas,
Ciudad de la Habana, Cuba. Inflamm Res
2002 Jul;51(7):351-6 |
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Phycocyanin
provides protection to liver enzymes
Department
of Organic Chemistry, Indian Institute
of Science, Bangalore, 560 012, India.
Biochem Biophys Res Commun 1998 Aug
19;249(2):428-31 |
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Antioxidant
nature of C-phycocyanin protects the renal
cell against oxalate-induced injury and
may be a nephroprotective agent.
Department
of Medical Biochemistry, Dr. AL Mudalia
Post-Graduate Institute of Basic Medical
Sciences, University of Madras, Taramani,
Chennai-600 113, India. Clin Chim Acta.
2004 Oct; 348(1-2):199-205 |
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CELLS AND BLOOD SYSTEM PROTECTION
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Phycocyanin and polysaccharides enhanced bone marrow reproduction, growth of thymus and spleen and biosynthesis of serum protein.
Zhang Cheng-Wu, et. al. Effects of polyssacharides and phycocyanin from spirulina on peripheral blood and hematopoietic system of bone marrow in mice. Second Asia Pacific Conf. Ibid, April, 1994
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Phycocyanin,
a novel hypocholesterolemic protein derived
from spirulina platensis, can powerfully
influence serum cholesterol concentrations
and impart a stronger hypocholesterolemic
activity than SPC (Spirulina platensis
concentrate) in animals.
Department of Applied Life Science,
Faculty of Applied Biological Sciences,
Gifu University, Gifu 501-1193, Japan
J Nutr.2005 Oct;135(10):2425-30
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Phycocyanin
may inhibit free radicals (such as hydroxyl
radicals) released from activated platelets,
which ultimately inhibits platelet aggregation.
These results strongly indicate that Phycocyanin
appears to represent a novel and potential
antiplatelet agent for treatment of arterial
thromboembolism.
Graduate Institute of Pharmacology, and
Graduate Institute of Medical Sciences,
Taipei Medical University, Taipei 110,
Taiwan. J Agric Food Chem. 2005 Oct
5; 53(20):7734-40. |
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Algal
phycocyanin promotes growth of human cells
in culture.
Food Additive Laboratory, National Food
Research Institute, Ibaraki, Japan In
Vitro Cell Dev Biol 1988 Oct;24(10):1057-60
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C-phycocyanin
protected cerebellar granule cells from
the apoptosis induced by deprivation.
Unitat de
Farmacologia I Farmacognosia, Facultat
de Farmacia, Nucli Universitari de Pedralbes,
Barcelona, Spain. Naunyn Schmiedebergs
Arch Pharmacol 2001 Aug; 364(2):96-104 |
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Phycocyanin
could be used to treat oxidative stress-induced
neuronal injury inneurodegenerative diseases,
such as Alzheimers and Parkinsons.
Unitat de Farmacologia I Farmacognosia,
Facultat de Farmacia, Universitat de Barcelona,
Spain. Neurosci Lett 1999 Dec 3;276(2):
75-8 |
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Phycocyanin
is a cytotoxic photosensitizer that exhibits
specific binding to pluque and is activated
at a wavelength minimally absorbed by
blood. These properties suggest potential
therapeutic use for plaque localization
and regression.
Department of Medicine, University
of California, Irvine 92717 Lasers Surg
Med 1988;8(1):10-7 |
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Phycocyanin
proved to be almost sixteen times more
efficient as an antioxidant than trolox
and about twenty times more efficient
than ascorbic acid. Our results provide
evidence of the protective effect of phcocyanin
against haemolysis induced by peroxyl
radicals in human erythrocytes, which
seems to be due to the scavenging action
of the radicals in the aqueous phase.
Thus inhibiting chain of initiation of
lipid peroxidation, in a similar manner
to trolox and ascorbic acid.
Department of Pharmacology, National Center
for Scientific Research, PO Box 6412.
Havana City, Cuba. |
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PROTECTION AGAINST RADIATIONS
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Spirulinas proven health benefits for child victims of Chernobyl radiation spirulina reduced urine radioactivity levels by 50% in only 20 days. No side effects were registered.
Sokolovskiy, V.Corres. from the First Secretary BSSR Mission to the United Nations, May 20, 1991. |
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Use of spirulina to reduce allergic reactions to radiation sickness, based on a study of 270 children living in highly radioactive areas consuming spirulina lowered the levels of IgE in the blood.
Evets, P. et. al. Means to normalise the levels of immunoglobulin E, using the food supplement spirulina. Grodenski State Medical Univ. Russian Fed Comm Patents and Trade. Patent (19)RU (11)2005486. Jan. 15, 1994. |
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Wistar
rats have been exposed to X-rays with
a dose of 5 Gy. Significant decrease in
dehydrogenase activity, energy-rich phosphate
level and efficiency of antioxidant defence
and significant increase in pyruvate amount
were observed within 4 weeks. It was also
found that the feeding of exposed rats
with phycocyanin lead to correcting effect.
Mechnikov
Odessa State University, Ukraina Radiats
Biol Radioecol 2000 May-Jun;40(3):310-4 |
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The
radioprotective effect of an extract
of Spirulina platensis has been studied
using the micronucleus test in polychromatic
erythrocytes of bone marrow of mice.
In this system the extract caused a
significant reduction of the micronucleus
frequencies induced by gamma-radiation.
Department
of Biotechnology, zhongkai Argriculture
and Technology College, Guangzhou Peoples
republic of China Toxicol Lett 1989
Aug;48(2):165-9 |
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ANTI-CANCER
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Small dosage of phycocyanin daily maintains or accelerates normal control cell functions that prevents generation of malignancy such as cancer or inhibits its growth or recurrence.
Dainippon Ink x Chemicals and Tokyo Kenkyukai (inventors and assignee). Anti-tumor agents containing phycobilin also used to treat ulcers and hemorrhoidal bleeding. 1983, JP58065216 A 830418. |
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C-Phycocyanin,
the major light harvesting biliprotein
from Spirulina platensis is of greater
importance because of its various biological
and pharmacological properties. It is
a water soluble, non-toxic fluorescent
protein pigment with potent anti-oxidant,
anti-inflammatory and anti-cancer properties.
Department
of Animal Sciences, School of Life Sciences,
University of Hyderabad, Hyderabad 500046,
India. Biochem Pharmacol. 2004 Aug 1;68(3):453-62 |
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Phycocyanin
significantly inhibited the growth of
human leukemia K562 cells.
Medical School, Nanjing University, Nanjing,
2/0093, PR of China. |
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Phycocyanin,
a natural product, could be a possible
chemotherapeutic agent through its apoptotic
activity against tumor cells.
Centre for Cellular and Molecular Biology,
Hyderabad 500 007, India Mol Cancer
Ther.2003 Nov;2(11):1165-70 |
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The
recombinant ί subunit of C-phycocyanin
inhibits cell proliferation and induces
apoptosis Cancer Letters
Department of Biology. Georgia Cancer
Center, Georgia State University, University
Plaza, Atlanta, Ga30303. USA Received
16 January 2006, received in revised form
31 March 2006, accepted 6 April 2006. |
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ANTI-INFLAMMATORY
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The
anti-inflammatory effect of microalgae
spirulina was studied in Zymosan-induced
arthritis in mice. The anti-arthritic
effect exerted by spirulina as shown in
this model may be at least partly due
to the previously reported anti-inflammatory
and antioxidative properties of its constituent,
Phycocyanin.
Ozone International Center, Havana, Cuba
Mediators Inflamm 2002 Apr;11(2):75-9 |
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Phycocyanin
may result, at least partially, from inhibition
of prostaglandin E2 production and a moderate
inhibition of phospholipase A2 activity.
Departamento
de Farmacologia, Centro Nacional de Investigaciones
Cientificas, CNIC, Habana, Cuba Arzneimittelforschung
2000 Dec;50(12):1106-9 |
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Anti-inflammatory
activity of phycocyanin extract in acetic
acid-induced colitis in rats
Pharmacology Department, National Center
for Scientific Research, PO Box 6990,
Havan, Cuba |
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Phycocyanin
exerts inhibitory effects on tumor necrosis
factor-alpha(TNF alpha) and NO production
which might be ascribed to the antioxidative
properties of the biliprotein.
Department
of Pharmacology, National Center for Scientific
Research, Havana, Cuba Arzneimittelforschung
2001 Sep;51(9):733-6 |
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Phycocyanin
shows anti-inflammatory activity in four
experimental models of inflammation. Its
antioxidative and oxygen free radical
scavenging properties may contribute,
at least in part, to its anti-inflammatory
activity.
Depto. Farmacologia, Centro Nac. Invest.
Cientificas, CNIC, Habana, Cuba Inflamm
Res 1998 Aug;47(8):334-8 |
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